کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10603162 982464 2005 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Preparation and characterization of N-acetylchitosan, N-propionylchitosan and N-butyrylchitosan microspheres for controlled release of 6-mercaptourine
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Preparation and characterization of N-acetylchitosan, N-propionylchitosan and N-butyrylchitosan microspheres for controlled release of 6-mercaptourine
چکیده انگلیسی
In this paper, biodegradable N-acylchitosan microspheres were prepared by a water-in-oil (w/o) interfacial N-acylation method for controlled release of 6-mercaptourine (6-MP). Acetic, propionic and n-butyric anhydrides were used as reagents for the interfacial N-acylation reaction to prepare N-acetylchitosan, N-propionylchitosan and N-butyrylchitosan microspheres. The onset time for the gelation of N-acylchitosan microspheres increased with increasing the molecular weight of used anhydride. While, the particle sizes of N-acetylchitosan microspheres (>50 μm), N-propionylchitosan microspheres (20-50 μm) and N-butyrylchitosan microspheres (∼5 μm) decreased with the increase of substituted acyl chain length. The introduction of long acyl chains onto chitosan not only increased hydrophobicity, but also interfered crystallization of the polymer chains, leading to affecting the swelling and drug release properties of prepared N-acylchitosan microspheres. Drug release rates of the N-acylchitosan microspheres decreased in the sequence of N-propionylchitosan (t50%∼19 h)>N-butyrylchitosan (t50%∼36 h)>N-acetylchitosan (t50%>100 h), and were fitted with a two-phase percolation model. The enhancement of drug release for N-propionylchitosan and N-butyrylchitosan microspheres under lysozyme degradation were less significant than their N-acetylchitosan counterpart. The results suggested that the N-acylchitosan microspheres excipient as interesting candidates for drug delivery application.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 60, Issue 2, 6 May 2005, Pages 219-227
نویسندگان
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