Uniquely different PVA-xanthan gum irradiated membranes as transdermal diltiazem delivery device

► Xanthan gum content strongly influenced crystalline PVA morphology on irradiation. ► High molecular weight PVA-low xanthan gum combination produced fibrillar PVA. ► Conversely, low molecular weight PVA-xanthan gum produced fibrillar PVA. ► Fibrillar PVA produced mechanically stronger membrane than lamellar PVA. ► They show most sustained relaxation based transdermal diltiazem release than else.