The PEI-introduced CS shell/PMMA core nanoparticle for silencing the expression of E6/E7 oncogenes in human cervical cells

► We report the potential of CS-PEI-nanoparticles for DNA and siRNA delivery. ► Physicochemical property of CS-PEI/DNA and CS-PEI/siRNA complexes was investigated. ► CS-PEI/DNA-mediated gene transfection in SiHa shows high transfection efficiency. ► Silencing of HPV E6/E7 gene expression was achieved by CS-PEI/siRNA transfection.