Preparation and anticoagulant activity of a fucosylated polysaccharide sulfate from a sea cucumber Acaudina molpadioidea

► A new fucosylated polysaccharide sulfate was purified from a special sea cucumber, Acaudina molpadioidea. ► Two derivatives were prepared from native polysaccharide and their anticoagulant activities were investigated. ► Sulfated derivative showed a stronger anticoagulant ability than native polysaccharide and carboxymethylated derivative.