کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10606577 | 983083 | 2011 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Preparation, characterization, and biological evaluation of 6I,6IV-di-O-[α-l-fucopyranosyl-(1â6)-2-acetamido-2-deoxy-β-d-glucopyranosyl]-cyclomaltoheptaose and 6-O-[α-l-fucopyranosyl-(1â6)-2-acetamido-2-deoxy-β-d-glucopyranosyl]-cyclomaltoheptaose
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Preparation, characterization, and biological evaluation of 6I,6IV-di-O-[α-l-fucopyranosyl-(1â6)-2-acetamido-2-deoxy-β-d-glucopyranosyl]-cyclomaltoheptaose and 6-O-[α-l-fucopyranosyl-(1â6)-2-acetamido-2-deoxy-β-d-glucopyranosyl]-cyclomaltoheptaose Preparation, characterization, and biological evaluation of 6I,6IV-di-O-[α-l-fucopyranosyl-(1â6)-2-acetamido-2-deoxy-β-d-glucopyranosyl]-cyclomaltoheptaose and 6-O-[α-l-fucopyranosyl-(1â6)-2-acetamido-2-deoxy-β-d-glucopyranosyl]-cyclomaltoheptaose](/preview/png/10606577.png)
چکیده انگلیسی
6I,6IV-Di-O-[α-l-fucopyranosyl-(1â6)-2-acetamido-2-deoxy-β-d-glucopyranosyl]-cyclomaltoheptaose (βCD) {6I,6IV-di-O-[α-l-Fuc-(1â6)-β-d-GlcNAc]-βCD (5)} and 6-O-[α-l-fucopyranosyl-(1â6)-2-acetamido-2-deoxy-β-d-glucopyranosyl]-βCD {6-O-[α-l-Fuc-(1â6)-β-d-GlcNAc]-βCD (6)} were chemically synthesized using the corresponding authentic compounds, bis(2,3-di-O-acetyl)-pentakis(2,3,6-tri-O-acetyl)-βCD as the glycosyl acceptor and 2,3,4-tri-O-benzyl-α-l-fucopyranosyl-(1â6)-3,4-di-O-acetyl-2-deoxy-2-(2,2,2-trichloroethoxycarbonylamino)-d-glucopyranosyl trichloroacetimidate as the fuco-glucosaminyl donor. NMR confirmed that α-l-Fuc-(1â6)-d-GlcNAc was bonded by β-linking to the βCD ring. To evaluate biological efficiency, the biological activities of the new branched βCDs were examined. The cell detachment activity of 5 was lower than that of 6 in real-time cell sensing (RT-CES) assay, indicating that 5 has lower toxicity. In SPR analysis, 5 had a higher special binding with AAL, a fucose-recognizing lectin. These results suggest that 5 could be an efficient drug carrier directed at cells expressing fucose-binding proteins.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Research - Volume 346, Issue 13, 27 September 2011, Pages 1792-1800
Journal: Carbohydrate Research - Volume 346, Issue 13, 27 September 2011, Pages 1792-1800
نویسندگان
Takatoshi Nakagawa, Yuki Nishi, Akihiro Kondo, Yuko Shirai, Chie Honda, Michio Asahi, Toshiko Tanimoto,