کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10606578 | 983083 | 2011 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Highly diastereoselective conjugate addition of nitroalkanes to α,β-unsaturated sugar lactones for the efficient synthesis of chiral 2-pyrrolidones
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Highly diastereoselective conjugate addition of nitroalkanes to α,β-unsaturated sugar lactones for the efficient synthesis of chiral 2-pyrrolidones Highly diastereoselective conjugate addition of nitroalkanes to α,β-unsaturated sugar lactones for the efficient synthesis of chiral 2-pyrrolidones](/preview/png/10606578.png)
چکیده انگلیسی
A series of 4,5-substituted chiral γ-lactams were synthesized through a highly diastereoselective addition-rearrangement approach from 2,3-unsaturated sugar lactones. The single-crystal X-ray structure of one product indicated that the sugar ring was attacked from the axial side. Partial reduction of the nitro group produced N-hydroxy-γ-lactams, which were further reduced with TiCl3 to yield the 4,5-substituted chiral γ-lactams. The absolute configuration of C5 of the γ-lactam was determined by NOESY spectra.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Research - Volume 346, Issue 13, 27 September 2011, Pages 1801-1808
Journal: Carbohydrate Research - Volume 346, Issue 13, 27 September 2011, Pages 1801-1808
نویسندگان
Yan-Ping Li, Zhong-Jun Li, Xiang-Bao Meng,