کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10614693 | 987171 | 2013 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Reciprocating sliding wear behavior of alendronate sodium-loaded UHMWPE under different tribological conditions
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موضوعات مرتبط
مهندسی و علوم پایه
مهندسی مواد
بیومتریال
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
The aim of this study is to investigate the tribological behaviors and wear mechanisms of ultra-high molecular weight polyethylene (UHMWPE) loaded with alendronate sodium (ALN), a potential drug to treat osteolysis, under different normal loads and lubrication conditions. A mixture of UHMWPE powder and ALN (1.0Â wt.%) solution was dried and hot pressed. The static and dynamic friction coefficients of UHMWPE-ALN were slightly higher than those of UHMWPE except under normal load as 10Â N and in 25Â v/v % calf serum. The specific wear rates of UHMWPE-ALN and UHMWPE were the lowest in 25Â v/v % calf serum compared to those in deionized water or physiological saline. In particular, the specific wear rate of UHMWPE-ALN was lower than that of UHMWPE at 50Â N in 25Â v/v % calf serum. The main wear mechanisms of UHMWPE and UHMWPE-ALN in deionized water and UHMWPE in physiological saline were abrasive. The main wear mechanism of UHMWPE-ALN in physiological saline was micro-fatigue. In 25Â v/v % calf serum, the main wear mechanism of UHMWPE and UHMWPE-ALN was abrasive wear accompanied with plastic deformation. The results of Micro-XRD indicated that the molecular deformation of UHMWPE-ALN and UHMWPE under the lower stress were in the amorphous region but in the crystalline region at the higher stress. These results showed that the wear of UHMWPE-ALN would be reduced under calf serum lubricated, which would be potentially applied to treat osteolysis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Materials Science and Engineering: C - Volume 33, Issue 5, 1 July 2013, Pages 3001-3009
Journal: Materials Science and Engineering: C - Volume 33, Issue 5, 1 July 2013, Pages 3001-3009
نویسندگان
Jie Huang, Shuxin Qu, Jing Wang, Dan Yang, Ke Duan, Jie Weng,