Study on the genotoxicity of HA/ZrO2 composite particles in vitro

► HA/ZrO2 composite particles were prepared by sintering used powder of HA and ZrO2 of different proportions. ► Evaluate the genotoxicity of the HA/ZrO2 composite particle in vitro micronucleus test (MNT). ► The genotoxicity of the HA/ZrO2 composite particle increased with an increase in the proportion of ZrO2. ► The 30%wtHA/70% ZrO2 composite with 200 μg/mL concentration showed significant genotoxicity.