کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10614923 987181 2011 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Preparation of highly interconnected porous hydroxyapatite scaffolds by chitin gel-casting
موضوعات مرتبط
مهندسی و علوم پایه مهندسی مواد بیومتریال
پیش نمایش صفحه اول مقاله
Preparation of highly interconnected porous hydroxyapatite scaffolds by chitin gel-casting
چکیده انگلیسی
In this study, a simple and effective method for producing highly interconnected porous hydroxyapatite (HA) scaffolds was developed by combining gel-casting, particle-leaching and extrusion techniques. Chitin (CT) sol was used to disperse HA particles and wax spheres were introduced as porogens for their excellent deformability. In extrusion process, the accumulated wax spheres in point-to-point contact can transform into surface-to-surface contact by means of the extrusion pressure. Thus, the obtained porous HA scaffolds exhibited an interconnected channel network after leaching out of the porogens. The results showed that the scaffolds prepared by different size of wax spheres exhibited nearly the same volumetric porosity of about 86%, while the compressive strengths decreased as the pore size increased. Therefore, the method developed can be used to effectively tailor the pore size of HA scaffolds while maintaining a high porosity. The highly porous HA scaffolds with excellent interconnectivity are expected to be a promising bone substitute in clinical practice.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Materials Science and Engineering: C - Volume 31, Issue 3, 8 April 2011, Pages 697-701
نویسندگان
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