کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10624985 | 989613 | 2014 | 26 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Mechanical reinforcement of injectable calcium phosphate cement/silk fibroin (SF) composite by mineralized SF
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی مواد
سرامیک و کامپوزیت
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Mechanical reinforcement of injectable calcium phosphate cement/silk fibroin (SF) composite by mineralized SF Mechanical reinforcement of injectable calcium phosphate cement/silk fibroin (SF) composite by mineralized SF](/preview/png/10624985.png)
چکیده انگلیسی
Calcium phosphate cements (CPCs) are promising injectable orthopedic materials with excellent biocompatibility and osteoconductivity. However, the inferior mechanical strength limits their use to low load-bearing areas only. In this study, we synthesized hydroxyapatite (HA)-silk fibroin (SF) complex through a co-precipitation method and supplemented it to an injectable CPC/SF composite. We found that the compressive strength of the three-component composite, CPC/HA-SF/SF, kept increasing with HA-SF content if it did not exceed 3Â wt%. Such a reinforcing effect was likely the result of improved interfacial integrity and oriented growth of HA crystals in CPC/SF composite upon HA-SF supplementation. The setting time of CPC/HA-SF/SF composites decreased as a function of HA-SF content, with no apparent effect on injectability. Moreover, the CPC/HA-SF/SF composites showed good biocompatibility both in vitro and in vivo. Such composites hold good promise for many orthopedic applications, including serving as filler materials for minimally invasive surgeries to treat vertebral fractures.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Ceramics International - Volume 40, Issue 9, Part A, November 2014, Pages 13987-13993
Journal: Ceramics International - Volume 40, Issue 9, Part A, November 2014, Pages 13987-13993
نویسندگان
Chengbin Cao, Hao Li, Jun Li, Chen Liu, Huilin Yang, Bin Li,