A simple pathway in preparation of controlled porosity of biphasic calcium phosphate scaffold for dentin regeneration

A simple pathway in preparation of biphasic calcium phosphate scaffold of hydroxyapatite/beta-tricalcium phosphate with controlled pore size, shape and porosity using phosphoric acid and calcium carbonate was successfully developed. Microporosity was controlled by adjusting temperature and soaking time of the sintering process while macroporosity was obtained through addition of polyethylene spherical particles. The advantage of this method is that a highly pure biphasic calcium phosphate scaffold consisting of hydroxyapatite/beta-tricalcium phosphate in a controlled ratio of 20/80 with a mean pore size of 300 μm and 65% porosity can be produced. These properties of scaffold are of high potential for use in dentin regeneration.