کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10652262 | 1002025 | 2005 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
On the physical transformations of processed pharmaceutical solids
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موضوعات مرتبط
مهندسی و علوم پایه
مهندسی مواد
دانش مواد (عمومی)
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چکیده انگلیسی
Atomic force microscopy Phase Imaging, an adaptation of Tapping Mode AFM was used to visualise physico-mechanical variations on the surface of crystalline materials after being subjected to mechanically induced lattice damage. Large crystals (100-500 μm) of lactose were nucleated on AFM sample stubs, imaged and subjected to a milling process. The milled samples were then imaged at specific humidity using Phase Imaging. Phase and Amplitude images of the re-crystallised lactose suggested an ordered crystalline state with multiple platelets present across the surface. In comparison, the morphology and surface properties after a 1-min mill time suggested milling had a dramatic effect on the surface characteristics of the re-crystallised lactose. Phase and Topographical imaging during exposure to elevated humidities (70% RH) indicated both morphological and physico-mechanical changes that may be linked to surface amorphous re-crystallisation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Micron - Volume 36, Issue 6, August 2005, Pages 519-524
Journal: Micron - Volume 36, Issue 6, August 2005, Pages 519-524
نویسندگان
Robert Price, Paul M. Young,