کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10729738 | 1042085 | 2005 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Labelling of manganese-based magnetic resonance imaging (MRI) contrast agents with the positron emitter 51Mn, as exemplified by manganese-tetraphenyl-porphin-sulfonate (MnTPPS4)
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موضوعات مرتبط
مهندسی و علوم پایه
فیزیک و نجوم
تشعشع
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چکیده انگلیسی
The potential tumor seeking MRI contrast agent MnTPPS4 was labelled with the positron emitting nuclide 51Mn in no-carrier-added (n.c.a.) form. The complex formation kinetics were investigated and the apparent rate constants were determined under pseudo-first-order conditions. The derived bimolecular rate constants gave the Arrhenius parameters EA=84Â kJÂ molâ1 and A=2Ã1012Â sâ1Â Mâ1. Optimum labelling conditions were derived (radiochemical yields>99% possible, effective yields about 32%). Separation and purification of n.c.a. 51MnTPPS4 were performed for potential human use. All impurities were<1%.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Applied Radiation and Isotopes - Volume 62, Issue 5, May 2005, Pages 711-720
Journal: Applied Radiation and Isotopes - Volume 62, Issue 5, May 2005, Pages 711-720
نویسندگان
A.T.J. Klein, F. Rösch, H.H. Coenen, S.M. Qaim,