کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10730501 | 1042560 | 2009 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The rabbit biodistribution of a therapeutic dose of zoledronic acid labeled with Tc-99m
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
فیزیک و نجوم
تشعشع
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: The rabbit biodistribution of a therapeutic dose of zoledronic acid labeled with Tc-99m The rabbit biodistribution of a therapeutic dose of zoledronic acid labeled with Tc-99m](/preview/png/10730501.png)
چکیده انگلیسی
The aim of the present study was to label a therapeutic dose of zoledronic acid (ZOL) with Tc-99m, evaluate its in vitro stability and compare its biodistribution to 99mTc-methylene biphosphonate (99mTc-MDP) in normal rabbits. Preparation of 0.50Â mg of 99mTc-ZOL was carried out by the reduction of 99mTc-pertechnetate in the presence of stannous chloride. The radiolabeling efficiency was found to be greater than 99%. The labeled complex was stable at least up to 6Â h at room temperature determined by paper chromatography. 99mTc-ZOL and 99mTc-MDP were administered intravenously to the rabbits for scintigraphic studies. Between 99mTc-ZOL and 99mTc-MDP, there were no significant differences in the ratios of femur/BG and lumbar vertebrae/BG, whereas epiphysis/BG and the kidney/BG ratios of 99mTc-MDP were higher than 99mTc-ZOL at the static studies.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Applied Radiation and Isotopes - Volume 67, Issue 9, September 2009, Pages 1616-1621
Journal: Applied Radiation and Isotopes - Volume 67, Issue 9, September 2009, Pages 1616-1621
نویسندگان
Makbule Asikoglu, Funda Gamze Durak,