کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10730509 1042560 2009 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Preparation and bioevaluation of a 99mTc-labeled chlorambucil analog as a tumor targeting agent
موضوعات مرتبط
مهندسی و علوم پایه فیزیک و نجوم تشعشع
پیش نمایش صفحه اول مقاله
Preparation and bioevaluation of a 99mTc-labeled chlorambucil analog as a tumor targeting agent
چکیده انگلیسی
Chlorambucil belongs to a group of nitrogen mustards which are used for the treatment of variety of cancers. Hence, a chlorambucil derivative has been radiolabeled with [99mTc(CO)3(H2O)3]+ core and its efficacy as a tumor targeting agent has been evaluated. Radiochemical yield of the complex was >98% as observed by HPLC. The in vitro studies in MCF-7 breast cancer cells showed about 30% inhibition of the radiolabeled complex in presence of the cold chlorambucil derivative. Biodistribution studies in Swiss mice bearing fibrosarcoma tumor showed an uptake of 3.2±0.3% ID/g at 3 h.p.i.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Applied Radiation and Isotopes - Volume 67, Issue 9, September 2009, Pages 1644-1649
نویسندگان
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