Reciprocal interactions between sleep, circadian rhythms and Alzheimer's disease: Focus on the role of hypocretin and melatonin

► AD pathology leads to sleep disturbances and circadian disruptions. ► Sleep disturbances have a negative influence on the quality of life of patients and care givers. ► Sleep deprivation and hypocretin increase Aβ levels and plaque deposition. ► Melatonin has anti-amyloidgenic properties. ► Important role of both melatonin and hypocretin in modulating AD pathophysiology.