کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10737269 | 1046374 | 2005 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Reversal of age-related deficits in object recognition memory in rats with l-deprenyl
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
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چکیده انگلیسی
The monoamine-oxidase-B (MAO-B) inhibitor l-deprenyl (selegiline) is effective in treating Parkinson's disease and possibly cognitive deficits associated with aging, Alzheimer's disease and HIV dementia. The aim of the present study was to investigate the effects of l-deprenyl on short- and long-term recognition memory in aged rats. Young adult and aged male Wistar rats were trained in a novel object recognition task. Retention test trials were carried out at 1.5 or 24Â h after training. Aged rats showed impaired recognition memory retention 24Â h after training when compared to young animals. Treatment with a daily systemic injection of l-deprenyl (1.0Â mg/kg) for 21 days reversed the memory impairment. A control experiment indicated that l-deprenyl did not affect sensorimotor functions. The results suggest that l-deprenyl reverses age-related deficits in long-term recognition memory.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Gerontology - Volume 40, Issue 6, June 2005, Pages 506-511
Journal: Experimental Gerontology - Volume 40, Issue 6, June 2005, Pages 506-511
نویسندگان
Maria Noêmia M. de Lima, Daniela C. Laranja, Fábio Caldana, Elke Bromberg, Rafael Roesler, Nadja Schröder,