کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10737283 | 1046375 | 2005 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Modulation of apolipoprotein E and interleukin-1β in the aging liver
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Modulation of apolipoprotein E and interleukin-1β in the aging liver Modulation of apolipoprotein E and interleukin-1β in the aging liver](/preview/png/10737283.png)
چکیده انگلیسی
With aging there is a decline in liver function that includes reductions in hepatic blood flow, metabolite clearance, and impaired tissue repair following injury. An increase in inflammatory signaling is often observed during aging, with inflammation potentially mediating age-related changes in the liver. Apolipoprotein E (ApoE) is primarily produced by the liver and has been shown to possess anti-inflammatory properties in a variety of paradigms and experimental settings. In the present study, we correlated age-related alterations in ApoE expression with age-related changes in the cytokine interleukin-1 beta (IL-1β), in the liver of rats of increasing age. A significant increase in ApoE mRNA, and a significant decrease in IL-1β mRNA, was seen with increasing age. At the protein level, ApoE expression increased with aging, although IL-1β expression remained constant. No correlation was found between ApoE and IL-1β expression at the mRNA or protein level. Taken together, these studies demonstrate that ApoE expression is altered during normal aging, and indicates that there is no correlation between ApoE and IL-1β expression in the aging liver.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Gerontology - Volume 40, Issue 5, May 2005, Pages 409-415
Journal: Experimental Gerontology - Volume 40, Issue 5, May 2005, Pages 409-415
نویسندگان
Jillian R. Gee, Qunxing Ding, Jeffrey N. Keller,