Redox regulation of the epigenetic landscape in Cancer: A role for metabolic reprogramming in remodeling the epigenome

► Cancer is a disease associated with changes in metabolism, redox, and gene expression. ► The mechanisms leading to epigenetic alterations during carcinogenesis are unknown. ► Epigenetic disruption of cancer genes is linked to aberrant mitochondrial metabolism. ► Metabolic redox changes alter cofactor availability to enzymes that alter chromatin. ► Aberrant metabolic and redox changes cause epigenetic instability in cancer.