Role of Nox4 in murine models of kidney disease

► The role of Nox4 for renal pathology was studied using knockout mice. ► Nox4 knockout did not impair but rather increased diabetes I-induced albuminuria. ► Nox4 knockout did not attenuate but rather enhanced fibrosis after ureter ligation. ► Progression of renal failure was Nox4 independent in the remnant kidney model.