کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10738064 | 1046682 | 2011 | 15 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The role of glutathione S-transferase P in signaling pathways and S-glutathionylation in cancer
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کلمات کلیدی
S-glutathionylationmyeloproliferationpost-translational modification - اصلاح post-translationalCancer drug development - توسعه داروهای سرطانCancer - سرطانSignaling pathways - مسیرهای سیگنالینگbone marrow - مغز استخوانGenetic polymorphisms - پلیمورفیسم ژنتیکیGlutathione - گلوتاتیونglutathione S-transferase - گلوتاتیون S-ترانسفراز
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: The role of glutathione S-transferase P in signaling pathways and S-glutathionylation in cancer The role of glutathione S-transferase P in signaling pathways and S-glutathionylation in cancer](/preview/png/10738064.png)
چکیده انگلیسی
Glutathione S-transferase P is abundantly expressed in some mammalian tissues, particularly those associated with malignancies. While the enzyme can catalyze thioether bond formation between some electrophilic chemicals and GSH, novel nondetoxification functions are now ascribed to it. This review summarizes recent material that implicates GSTP in mediating S-glutathionylation of specific clusters of target proteins and in reactions that define a negative regulatory role in some kinase pathways through ligand or protein:protein interactions. It is becoming apparent that GSTP participates in the maintenance of cellular redox homeostasis through a number of convergent and divergent mechanisms. Moreover, drug platforms that have GSTP as a target have produced some interesting preclinical and clinical candidates.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Free Radical Biology and Medicine - Volume 51, Issue 2, 15 July 2011, Pages 299-313
Journal: Free Radical Biology and Medicine - Volume 51, Issue 2, 15 July 2011, Pages 299-313
نویسندگان
Kenneth D. Tew, Yefim Manevich, Christina Grek, Ying Xiong, Joachim Uys, Danyelle M. Townsend,