Protection against peroxynitrite by pseudoperoxidase from Leishmania major

► Leishmania major pseudoperoxidase acts as a scavenger of peroxynitrite. ► Peroxynitrite reacts with the six-coordinate low-spin heme of this protein to help catalysis. ► L. major pseudoperoxidase is located at the plasma membrane of amastigotes. ► This protein plays an important role in the virulence of Leishmania.