Longevity-promoting effects of 4-hydroxy-E-globularinin in Caenorhabditis elegans

► 4-Hydroxy-E-globularinin (4-HEG) is a natural molecule isolated from the medicinal plant Premna integrifolia. ► We examined the life span of wild-type N2 Caenorhabditis elegans and daf-16, sir-2.1, and mev-1 mutants. ► 4-HEG reduced reactive oxygen species levels and fat accumulation in the worms. ► 4-HEG extended the life span of worms via DAF-16 activation.