Positive regulation of NADPH oxidase 5 by proinflammatory-related mechanisms in human aortic smooth muscle cells

► Nox5 activity and expression are increased in IFNγ-exposed human aortic SMCs. ► NF-kB, AP-1, and STAT1/STAT3 regulate Nox5 promoter, Nox5 message, and protein. ► Free radicals generated by up-regulated Nox5 may contribute to vascular dysfunction.