Nrf2 deficiency in myeloid cells is not sufficient to protect mice from high-fat diet-induced adipose tissue inflammation and insulin resistance

► Global Nrf2 deficiency impaired diet-induced inflammation and insulin resistance. ► Myeloid Nrf2 deficiency did not affect proinflammatory gene expression in adipocytes. ► Cross talk between macrophages and adipocytes was independent of macrophage Nrf2. ► Myeloid Nrf2 deficiency was not sufficient to protect mice from diet-induced insulin resistance.