Essential role of intracellular glutathione in controlling ascorbic acid transporter expression and function in rat hepatocytes and hepatoma cells

► Glutathione-dependent ascorbic acid acquisition in rat hepatocytes. ► Differential regulation of ascorbic acid transporter expression in rat hepatocytes. ► Glutathione does not regulate ascorbic acid transport in human hepatoma cells. ► Absence of SVCT2 transporter expression in glutathione-depleted rat hepatoma cells.