Identification of Rhit as a novel transcriptional repressor of human Mpv17-like protein with a mitigating effect on mitochondrial dysfunction, and its transcriptional regulation by FOXD3 and GABP

► Human regulator of heat-induced transcription (RhitH) is involved in transcriptional regulation of human Mpv17-like protein (M-LPH). ► FOXD3 and GABP are involved in transcriptional regulation of RhitH. ► M-LPH reduces intracellular H2O2 and loss of mitochondrial membrane potential. ► Our data suggest that M-LPH has a mitigating effect on mitochondrial dysfunction.