Keywords: Asthma; bioinformatics; diisocyanate; electrophoretic mobility shift assay; functional genomics; gene regulation; genetic; histone; isocyanate; luciferase assay; next-generation sequencing; occupational asthma; oligonucleotide; single nucleotide polymorph
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Keywords: Der p; Dermatophagoides pteronyssinus; Dex; dexamethasone; ELISA; enzyme-linked immunosorbent assay; EMSA; electrophoretic mobility shift assay; FBS; foetal bovine serum; GMCSF; granulocyte-macrophage colony-stimulating factor; GMP; good manufacturing pra
Keywords: TFR; transcription factor of the TetR family; EMSA; electrophoretic mobility shift assay; LBD; ligand-binding domain; DBD; DNA-binding domain; Whole cell biosensor; Actinobacteria; Secondary metabolite; Antibiotic; Polyketide; TetR repressor protein;
Keywords: Retroviral vector; Kruppel-associated box-containing zinc finger proteins (KRAB-ZFPs); Zinc finger protein 809 (ZFP809); KRAB-ZFP; Kruppel-associated box-containing zinc finger protein; ZFP809; zinc finger protein 809; PBS; primer-binding site; MoMLV; Mol
Keywords: TUNEL; terminal deoxynucleotidyl transferase dUTP nick-end labeling; ELISA; enzyme-linked immunosorbent assay; DNA; deoxyribonucleic acid; TNFα; tumor necrosis factor-alpha; Foxa2; forkhead box protein A2; HNF6; hepatocyte nuclear factor 6; C/EBPα; CCAA
Keywords: EMT; epithelial-mesenchymal transition; TF; transcription factor; ZF; zinc finger; TSS; transcription start site; MD; molecular dynamics; EMSA; electrophoretic mobility shift assay; ChIP; chromatin immunoprecipitation assay; PDB; Protein Data Bank; SS;
Keywords: AP-1; Activator protein-1; APE; Apurinic/apyrimidinic endonuclease; ARE; Antioxidant response element; ChIP; Chromatin immunoprecipitation; CRE; cAMP response element; CREB; CRE binding protein; Egr-1; Early growth response factor-1; EMSA; Electrophoretic
Keywords: 3OC6-HSL; 3-oxohexanoyl homoserine lactone; 3OC12-HSL; N-(3-oxododecanoyl)-l-homoserine lactone; ABC; the ATP (adenosine triphosphate)-binding cassette superfamily; ABI-PP; AcrAB/MexAB-specific inhibitor of pyridopyrimidine derivative; AHL; N-acylhomoseri
Chd1p recognizes H3K36Ac to maintain nucleosome positioning near the transcription start site
Keywords: Chromatin remodeling; Nucleosome sliding; H3K36Ac; Chd1p; Saccharomyces cerevisiae; CHD; Chromo-helicase/ATPase DNA-binding; Chd1p; Chromo-helicase/ATPase DNA-binding protein 1; CHROMO; chromodomain; EMSA; Electromobility shift assays; H3K4me3; tri-methyl
Functional analysis of a novel ENG variant in a patient with hereditary hemorrhagic telangiectasia (HHT) identifies a new Sp1 binding-site
Keywords: Ab; antibody; ACTB; β-actin; ACVRL1; Activin A Receptor type II-Like Kinase 1; AVM; ArterioVenous Malformation; BMP; Bone Morphogenetic Protein; BMPR2; Bone Morphogenetic Protein Receptor Type 2; CAVM; Cerebral ArterioVenous Malformation; CTRL; control;
The nuclear receptor NOR-1 modulates redox homeostasis in human vascular smooth muscle cells
Keywords: Vascular remodeling; Atherosclerosis; ROS; NOR-1; NOX; CM-H2DCFDA; Chloromethyl derivative of dichlorodihydrofluorescein diacetate; CAD; Coronary artery disease; DHE; Dihydroethidium; EMSA; Electrophoretic mobility shift assay; GADPH; Glyceraldehyde 3-pho
KRAB-containing zinc finger protein ZNF496 inhibits breast cancer cell proliferation by selectively repressing ERα activity
Keywords: KZNF; KRAB-containing zinc finger; DBD; DNA binding domain; ERα; estrogen receptor alpha; RFS; recurrence-free survival; KRAB; Krüppel-associated box; TRIM28; tripartite motif-containing 28; NSD1; nuclear receptor binding SET domain protein 1; JMJ; Jumo
Intrinsically disordered N-terminal domain of the Helicoverpa armigera Ultraspiracle stabilizes the dimeric form via a scorpion-like structure
Keywords: NRs; nuclear receptors; NTD; N-terminal domain; DBD; DNA-binding domain; LBD; ligand-binding domain; EcR; ecdysone receptor; Usp; Ultraspiracle; IDR; intrinsically disordered region; HaUsp; Usp from Helicoverpa armigera; HaUsp_ÎNTD; Usp from Helicoverpa
Coordinate regulation by transcription factors and DNA methylation in the core promoter region of SIRT6 in bovine adipocytes
Keywords: SIRT6; Promoter; Transcriptional regulation; DNA methylation; Bovine; Adipocyte; qPCR; real-time quantitative; CEBPβ; CCAAT enhancer binding protein beta; PAX6; paired box 6; KLF2; Kruppel-like factor 2; CMYB; myb proto-oncogene protein; NRF1; nuclear re
Role of GPx3 in PPARγ-induced protection against COPD-associated oxidative stress
Keywords: COPD; chronic obstructive pulmonary disease; ROS; reactive oxygen species; GSH; glutathione; GPx; GSH peroxidase; PPARγ; Peroxisome proliferator-activated receptor γ; NF-κB; nuclear factor-κB; CSE; cigarette smoke extract; HBE; human bronchial epithel
Naoxintong restores collateral blood flow in a murine model of hindlimb ischemia through PPARδ-dependent mechanism
Keywords: NXT; naoxintong; PAD; peripheral vascular disease; DVT; deep veins thrombus of lower limb; VEGF; vascular endothelial growth factor; p-Akt; phosphorylated-Akt; p-eNOS; phosphorylated-endothelial nitric oxide synthase; TUNEL; Terminal deoxynucleotidyl tran
Transcriptional regulation of galF by RcsAB affects capsular polysaccharide formation in Klebsiella pneumoniae NTUH-K2044
Keywords: CPS; capsular polysaccharide; EMSA; electrophoretic mobility shift assay; K. pneumoniae; Klebsiella pneumoniae; LPS; lipopolysaccharide; EPS; exopolysaccharide; LB; Luria-Bertani; MOI; multiplicity of infection; LDH; lactate dehydrogenase; RcsAB; galF; CP
Ginsenoside Rg3 sensitizes hypoxic lung cancer cells to cisplatin via blocking of NF-κB mediated epithelial-mesenchymal transition and stemness
Keywords: Lung cancer; 20 (R)-Ginsenoside; Hypoxia; Epithelial-mesenchymal transition; Stemness; Rg3; 20 (R)-Ginsenoside Rg3; EMT; epithelial-mesenchymal transition; NSCLC; non-small cell lung cancer; HIF-1α; hypoxia induced factor-1α; EMSA; electrophoretic m
Photoactivatable oligonucleotide probes to trap single-stranded DNA binding proteins: Updating the potential of 4-thiothymidine from a comparative study
Keywords: Photoaffinity labeling; Single-stranded DNA binding proteins; Human replication protein A; 4-thiothymidine; EMSA; electrophoretic mobility shift assays; MALDI-TOF MS; Matrix assisted laser desorption/Ionisation time-of-flight mass spectrometry; ODN; oligo
Phosphosulindac is efficacious in an improved concanavalin A-based rabbit model of chronic dry eye disease
Keywords: BSA; bovine serum albumin; Con A; concanavalin A; DED; dry eye disease; ELISA; enzyme-linked immunosorbent assay; EMSA; electrophoretic mobility shift assay; ERK; extracellular signal-regulated kinase; IC50; half-maximal inhibitory concentration; IL-1β;
Neuronal Growth Factor regulates Brain Specific Kinase 1 expression by inhibiting promoter methylation and promoting Sp1 recruitment
Keywords: NGF; DNA methylation; Brsk1; DNMT3B; MAPK; 5â²Aza-dC; 5-aza-2â²-deoxycytidine; AKT/PKB; Protein kinase B; BRSK 1/2; Brain-Specific Kinase 1/2; C-5; cytosine 5'; CNS; Central Nervous System; DNMT; DNA methyltransferase; EMSA; Electrophoretic Mobility S
The third to fifth zinc fingers play an essential role in the binding of ZFP809 to the MLV-derived PBS
Keywords: Retroviral vector; Kruppel-associated box-containing zinc finger proteins (KRAB-ZFPs); Zinc finger protein 809 (ZFP809); KRAB-ZFP; kruppel-associated box-containing zinc finger protein; PBS; primer-binding site; MoMLV; moloney murine leukemia virus; LTR;
DNA-HMGB1 interaction: The nuclear aggregates of polyamine mediation
Keywords: Nuclear aggregates of polyamines; HMGB1; EMSA; Atomic force microscopy; DNA conformational transitions; Supramolecular nanotubes;
PKG-1α mediates GATA4 transcriptional activity
Keywords: GATA4; GATA binding protein 4; NPPA; natriuretic peptide A; NPPB; natriuretic peptide B; MHC; myosin heavy chain; ERK; extracellular regulated protein kinases; p38 MAPK; p38 mitogen-activated protein kinases; PKC; protein kinase C; GSK 3β; glycogen synth
Astemizole-Histamine induces Beclin-1-independent autophagy by targeting p53-dependent crosstalk between autophagy and apoptosis
Keywords: AST; Astemizole; HIS; Histamine; H1R; Histamine H1 receptor; ROS; Reactive oxygen species; ER; Endoplasmic reticulum; PERK; Protein kinase R-like endoplasmic reticulum kinase; IRE1α; Inositol-requiring enzyme 1; ATF; Activating transcription factor; JNK;
C-termini are essential and distinct for nucleic acid binding of human NABP1 and NABP2
Keywords: CD; circular dichroism; dsDNA; double-stranded DNA; EMSA; electrophoretic mobility shift assay; HR; homologous recombination; ITC; isothermal titration calorimetry; MS; mass spectrometry; NABP1; nucleic acid binding protein 1; NABP2; nucleic acid binding
Bovine milk-derived exosomes for drug delivery
Keywords: Milk-derived exosomes; Drug delivery; Tumor-targeting; Chemotherapeutic drugs; Chemopreventive agents; miRNA; microRNA; MTT; 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; PBS; Phosphate-buffered saline; qRT-PCR; Quantitative reverse transc
Akt phosphorylates myc-associated zinc finger protein (MAZ), releases P-MAZ from the p53 promoter, and activates p53 transcription
Keywords: p53; Arf; Mdm2; Akt; MAZ; Phosphorylation; ChIP; chromatin immunoprecipitation; Dox; doxycycline; EMSA; electrophoretic mobility shift assay; IB; immunoblotting; IP; immunoprecipitation; Myr-Akt; myristoylatedAkt; siRNA; small interference RNA; WB; Wester
Expression of microRNA-195 is transactivated by Sp1 but inhibited by histone deacetylase 3 in hepatocellular carcinoma cells
Keywords: ChIP; chromatin immunoprecipitation; EMSA; electrophoretic mobility shift assay; EST; expression sequence tag; miRNA; microRNA; HAT; histone acetyltransferase; HCC; hepatocellular carcinoma; HDAC; histone deacetylase; qPCR; real-time quantitative RT-PCR
FHL3 differentially regulates the expression of MyHC isoforms through interactions with MyoD and pCREB
Keywords: MyHC; myosin heavy chain; FHL; four and half LIM domain protein; CRE; cyclic AMP-responsive element; CREB; cAMP-response-element-binding protein; PKA; cAMP-activited protein kinase A; MyoG; myogenin; MyoD; myogenic differentiation 1; SDS; Sodium Dodecyl S
Regulation of retinoid X receptor gamma expression by fed state in mouse liver
Keywords: RXRγ; Liver; Feeding; Glucose; Lipid metabolism; RXR; retinoid X receptor; PPARγ; peroxisome proliferator-activated receptor gamma; RAR; retinoic acid receptor; FXR; farnesoid X receptor; LXR; liver X receptor; SREBP-1c; sterol regulatory element-bindin
24-Methylenecycloartanyl ferulate, a major compound of γ-oryzanol, promotes parvin-beta expression through an interaction with peroxisome proliferator-activated receptor-gamma 2 in human breast cancer cells
Keywords: 24-Methylenecycloartanyl ferulate; Integrin-linked kinase; Parvin-β; PPAR-γ2; Akt1; 24-MCF; 24-methylenecycloartanyl ferulate; CAF; cycloartenyl ferulate; CH; calponin homology; ChIP; chromatin immunoprecipitation; CSF; campesteryl ferulate; DMEM; Dulbe
Hepatitis C virus NS3 protein enhances cancer cell invasion by activating matrix metalloproteinase-9 and cyclooxygenase-2 through ERK/p38/NF-κB signal cascade
Keywords: AP-1; activation protein-1; CMA; cell matrix adhesion; COX-2; cyclooxygenase-2; ECM; extracellular matrix; ELISA; enzyme-linked immunosorbent assay; EMSA; electrophoretic mobility shift assay; ERK; extracellular signal-regulated kinase; HBV; hepatitis B v
BCL-2 family protein, BAD is down-regulated in breast cancer and inhibits cell invasion
Keywords: AIF; apoptosis inducible factor; AP-1; activator protein-1; AKT; protein kinase B; Apaf-1; apoptosis protease activating factor-1; BAD; Bcl-2-associated death promoter; BCL-2; B-cell lymphoma 2; BCLxL; B-cell lymphoma-extra large; BH3; Bcl-2 homology doma
Suggestive evidence on the involvement of polypyrimidine-tract binding protein in regulating alternative splicing of MAP/microtubule affinity-regulating kinase 4 in glioma
Keywords: EMSA; electrophoretic mobility shift assay; FGFR-1; fibroblast growth factor receptor-1; GBM; glioblastoma; GBM CSC; glioblastoma-derived cancer stem cell; hnRNP; heterogeneous nuclear ribonucleoprotein; ISS; intronic splicing silencer; IVS; intervening s
Functional interplay of SP family members and nuclear factor Y is essential for transcriptional activation of the human Calreticulin gene
Keywords: ATF6n; nuclear form of activating transcription factor 6; CALR; Calreticulin; ChIP; chromatin immunoprecipitation; CRM; cis-regulatory module; EMSA; electromobility shift assay; ERSE; endoplasmic reticulum stress-response element; NFY; nuclear factor Y; S
LIM homeobox transcription factor Lhx2 inhibits skeletal muscle differentiation in part via transcriptional activation of Msx1 and Msx2
Keywords: ES cells; embryonic stem cells; DMEM; Dulbecco׳s modified Eagle׳s medium; FBS; fetal bovine serum; PS; penicillin-streptomycin; FGF-2; fibroblast growth factor-2; RT-PCR; reverse transcription PCR; Gapdh; glyceraldehyde 3-phosphate dehydrogenase; PBS; p
The Nuclear Factor κB pathway: A link to the immune system in the radiation response
Keywords: Nuclear Factor κB; Immune system; Cellular radiation response; Linear energy transfer; Bystander effect; Chemokines; A20 (TNFAIP3); tumor necrosis factor inducible protein 3; ARD; ankyrin repeat domain; ATM; ataxia telangiectasia mutated protein; β-TrCP
GIP1 may act as a coactivator that enhances transcriptional activity of LBD18 in Arabidopsis
Keywords: ASL; asymmetric leaves2-like; ARR7; Arabidopsis response regulator 7; BiFC; bimolecular fluorescence complementation; DEX; dexamethasone; EMSA; electrophoretic mobility shift assay; EXP; expansin; GBF; G-box binding factor; GIP1; GBF interacting protein 1
SREBP-2 negatively regulates FXR-dependent transcription of FGF19 in human intestinal cells
Keywords: ChIP; chromatin immunoprecipitation; DR-1; direct repeat separated by 1 nucleotide; EMSA; electrophoretic mobility shift assay; ER-8; everted repeat separated by 8 nucleotides; FXR; farnesoid X receptor; FGF19; fibroblast growth factor 19; GST; glutathion
ATF3 represses PPARγ expression and inhibits adipocyte differentiation
Keywords: ATF3; activation transcription factor 3; ATF/CRE; ATF/CREB responsive element; C/EBP; CCAAT/enhancer-binding proteins; ChIP; chromatin immunoprecipitation; EMSA; electrophoretic mobility shift assay; ER; endoplasmic reticulum; aP2; adipocyte fatty acid bi
Rad GTPase inhibits the NFκB pathway through interacting with RelA/p65 to impede its DNA binding and target gene transactivation
Keywords: Cavβ; calcium channel, voltage-dependent, beta subunit; CaM; calmodulin; EMSA; electrophoretic mobility shift assay; Gem; GTP binding protein overexpressed in skeletal muscle; Gmip; Gem interacting protein; GST; glutathione S-transferase; IκB; inhibitor
Carboxylation of cytosine (5caC) in the CG dinucleotide in the E-box motif (CGCAG|GTG) increases binding of the Tcf3|Ascl1 helix-loop-helix heterodimer 10-fold
Keywords: C; cytosine; B-HLH; basic-helix-loop-helix; E-Box; Enhancer Box; Tcf3; transcription factor 3; Tcf4; transcription factor 4; Tcf12; transcription factor 12; Ascl1; Achaete-scute homolog 1; 5mC; 5-methylcytosine; 5hmC; 5-hydroxymethylcytosine; 5fC; 5-formy
Production of pure and functional RNA for in vitro reconstitution experiments
Keywords: DEPC; diethylpyrocarbonate; EMSA; electrophoretic mobility shift assay; GST; glutathion S-transferase; HPLC; high pressure liquid chromatography; MBP; maltose-binding protein; PAGE; polyacrylamide gel electrophoresis; RNP; ribonucleoprotein particle; RNA;
Sequential binding of FurA from Anabaena sp. PCC 7120 to iron boxes: Exploring regulation at the nanoscale
Keywords: Fur; Ferric uptake regulator; AFM; atomic force microscopy; UV; ultra-violet; SDS; sodium dodecyl-sulfate; DTT; dithiothreitol; EMSA; Electrophoretic mobility shift assays; PfurA; furA promoter; Ferric uptake regulator; Atomic force microscopy; Transcript
PTEN inhibits the invasion and metastasis of gastric cancer via downregulation of FAK expression
Keywords: PTEN; phosphatase and tensin homolog; FAK; focal adhesion kinase; AKT; protein kinase B; NF-κB; nuclear factor B or NF-kappaB; ChIP; chromatin immunoprecipitation; EMSA; electrophoretic mobility shift assay; DAPI; 4â²,6-diamidino-2-phenylindole; Focal a
Phosphorylated Sp1 is the regulator of DNA-PKcs and DNA ligase IV transcription of daunorubicin-resistant leukemia cell lines
Keywords: DNR; daunorubicin; NHEJ; non-homologous end-joining; MDR; multidrug resistance; DSB; DNA-double-strand break; EMSA; electrophoresis mobility shift assay; ChIP; chromatin immunoprecipitation; Multidrug-resistant cell line; Daunorubicin; NHEJ; DNA-PKcs; DNA
As a novel p53 direct target, bidirectional gene HspB2/αB-crystallin regulates the ROS level and Warburg effect
Keywords: αBC; αB-crystallin; ActD; Actinomycin D; ChIP; chromatin immunoprecipitation; EMSA; Electrophoretic Mobility Shift; HK2; hexokinase II; HspB2; heat shock protein B2; RCC; renal cell carcinoma; ROS; reactive oxygen species; SCO2; cytochrome c oxidase 2;
Serine 249 phosphorylation by ATM protein kinase regulates hepatocyte nuclear factor-1α transactivation
Keywords: HNF; hepatocyte nuclear factor; MODY; maturity onset diabetes of the young; ATM; ataxia telangiectasia mutated; EMSA; electrophoretic mobility shift assay; ChIP; chromatin immunoprecipitation; IB; immunoblot; R.L.U; relative luciferase units; HNF1α; ATM;
Redox state of p63 and p73 core domains regulates sequence-specific DNA binding
Keywords: p53CON; p53 consensus sequence; diamide; azodicarboxylic acid bis[dimethylamide]; DTT; dithiothreitol; p53CD; GSTp53CD (aa 94-312); p63CD; GSTp63CD (aa 114-349); p73CD; GSTp73CD (aa 104-339); p53; full length p53; p53DBD; p53CD (aa 94-312); DBD; c