کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10754060 | 1050350 | 2014 | 14 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Bacterial multidrug efflux pumps: Mechanisms, physiology and pharmacological exploitations
ترجمه فارسی عنوان
پمپ فاضلاب چند داروی باکتریایی: مکانیسم، فیزیولوژی و بهره برداری دارویی
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کلمات کلیدی
C4-HSLDMTSMREPIABCCCCPMFSMDCKtetraphenylphosphoniumNMPDNPPQSRNDN-acylhomoserine lactonesN-(3-Oxododecanoyl)-l-homoserine lactoneNature productDARPinPAβNEMSADDMTCSDBDBRCCTDTPPMICAHLMDR2,4-Dinitrophenol - 2،4-دینیتروفنلElectrophoretic mobility shift assay - آزمون تحرک تحرک الکتروفورزAntibiotics - آنتی بیوتیک هاEthidium - اتیدیمethidium bromide - اتیدیوم برومایدMinimum inhibitory concentration - حداقل غلظت مهاریC-terminal domain - دامنه C ترمینالDNA binding domain - دامنه اتصال DNATwo component system - دو جزء سیستمMate - رفیقPhysiology - فیزیولوژیMultidrug resistance - مقاومت چند داروییRegulation - مقرراتquorum sensing - مقیاس سنجشEfflux pump inhibitors - مهار کننده های پمپ EffluxEfflux pump inhibitor - مهار کننده پمپ EffluxProflavin - پروفلاوینDesigned ankyrin repeat protein - پروکسی تکرار شده آنکیرین را طراحی کردMultidrug efflux pumps - پمپ های چند مرحله ایMadin–Darby Canine Kidney - کلیه کلیوی کلیوی Madin-Darby
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
چکیده انگلیسی
Multidrug resistance (MDR) refers to the capability of bacterial pathogens to withstand lethal doses of structurally diverse drugs which are capable of eradicating non-resistant strains. MDR has been identified as a major threat to the public health of human being by the World Health Organization (WHO). Among the four general mechanisms that cause antibiotic resistance including target alteration, drug inactivation, decreased permeability and increased efflux, drug extrusion by the multidrug efflux pumps serves as an important mechanism of MDR. Efflux pumps not only can expel a broad range of antibiotics owing to their poly-substrate specificity, but also drive the acquisition of additional resistance mechanisms by lowering intracellular antibiotic concentration and promoting mutation accumulation. Over-expression of multidrug efflux pumps have been increasingly found to be associated with clinically relevant drug resistance. On the other hand, accumulating evidence has suggested that efflux pumps also have physiological functions in bacteria and their expression is subject tight regulation in response to various of environmental and physiological signals. A comprehensive understanding of the mechanisms of drug extrusion, and regulation and physiological functions of efflux pumps is essential for the development of anti-resistance interventions. In this review, we summarize the development of these research areas in the recent decades and present the pharmacological exploitation of efflux pump inhibitors as a promising anti-drug resistance intervention.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 453, Issue 2, 17 October 2014, Pages 254-267
Journal: Biochemical and Biophysical Research Communications - Volume 453, Issue 2, 17 October 2014, Pages 254-267
نویسندگان
Jingjing Sun, Ziqing Deng, Aixin Yan,