کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10738341 | 1046702 | 2011 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Antioxidant activity contributes to flavonol cardioprotection during reperfusion of rat hearts
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کلمات کلیدی
eNOSLVEDPLVDPrPPHRPAmI - AMII/R - I / RROS - ROSAntioxidant - آنتی اکسیدانischemia/reperfusion - ایسکمی / رپرفیوژنleft ventricle - بطن چپCardioprotection - حفاظت از قلبFree radicals - رادیکال آزادendothelial nitric oxide synthase - سنتاز اکسید نیتریک اندوتلیالAcute myocardial infarction - سکته قلبیPerfusion pressure - فشار پرفیوژنFlavonol - فلاونولHeart - قلب lactate dehydrogenase - لاکتات دهیدروژناز LDH - لاکتات دهیدروژناز به صورت مختصر شده LDH Horseradish peroxidase - پراکسیداز هوررادیشReactive oxygen species - گونههای فعال اکسیژن
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The mechanism of flavonol-induced cardioprotection is unclear. We compared the protective actions of a flavonol that inhibits calcium utilization and has antioxidant activity, 3â²,4â²-dihydroxyflavonol (DiOHF); a flavonol that affects only calcium activity, 4â²-OH-3â²-OCH3-flavonol (4â²-OH-3â²-OCH3F); and a water-soluble flavonol with selective antioxidant activity, DiOHF-6-succinamic acid (DiOHF-6-SA), in isolated, perfused rat hearts. Hearts were subjected to global ischemia for 20 min followed by 30 min reperfusion and were treated with vehicle (0.05% DMSO), DiOHF, 4â²-OH-3â²-OCH3F, or DiOHF-6-SA (all 10 μM, n = 5-8 per group). Flavonols were infused for 10 min before ischemia and during reperfusion. In vehicle-treated hearts, left-ventricular (LV) + dP/dt was reduced by 60% at the end of reperfusion compared to the preischemic level. Lactate dehydrogenase (LDH) release was elevated and endothelial NO synthase (eNOS) expression was lower in vehicle-treated hearts compared to shams. In comparison, DiOHF treatment improved LV function upon reperfusion, decreased LDH, and preserved eNOS expression. The antioxidant DiOHF-6-SA also preserved contractility, reduced LDH, and preserved eNOS expression. In contrast, hearts treated with 4â²-OH-3â²-OCH3F showed a degree of contractile impairment similar to that of the vehicle group. DiOHF and DiOHF-6-SA also exerted cardioprotection when given only during reperfusion and not when administered only before ischemia. Flavonol-induced cardioprotection relies on antioxidant activity and is mainly exerted during reperfusion.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Free Radical Biology and Medicine - Volume 51, Issue 7, 1 October 2011, Pages 1437-1444
Journal: Free Radical Biology and Medicine - Volume 51, Issue 7, 1 October 2011, Pages 1437-1444
نویسندگان
Cheng Xue Qin, Spencer J. Williams, Owen L. Woodman,