In cardiac myoblasts, cellular redox regulates FosB and Fra-1 through multiple cis-regulatory modules

► Norepinephrine dose dependently induces hypertrophy and apoptosis in cardiomyoctes. ► Hypertrophy and apoptosis are marked by the induction of FosB and Fra-1 respectively. ► Both fosB and fra-1 at induced at the transcript level by reactive oxygen species. ► Response to reactive species is mediated by multiple cis elements in their promoters. ► Redox signals merge at the cis-elements creating gene specific regulatory modules.