کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10738449 1046706 2011 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Current perspectives and challenges in understanding the role of nitrite as an integral player in nitric oxide biology and therapy
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
پیش نمایش صفحه اول مقاله
Current perspectives and challenges in understanding the role of nitrite as an integral player in nitric oxide biology and therapy
چکیده انگلیسی
Beyond an inert oxidation product of nitric oxide (NO) metabolism, current thinking posits a key role for nitrite as a mediator of NO signaling, especially during hypoxia. This concept has been discussed in the context of nitrite serving a role as an endogenous modulator of NO homeostasis, but also from a novel clinical perspective whereby nitrite therapy may replenish NO signaling and prevent ischemic tissue injury. Indeed, the relatively rapid translation of studies delineating mechanisms of action to ongoing and planned clinical trials has been critical in fuelling interest in nitrite biology, and several excellent reviews have been written on this topic. In this article we limit our discussions to current concepts and what we feel are questions that remain unanswered within the paradigm of nitrite being a mediator of NO biology.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Free Radical Biology and Medicine - Volume 51, Issue 4, 15 August 2011, Pages 805-812
نویسندگان
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