کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10738761 | 1046751 | 2009 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Gender-dependent impacts of body mass index and moderate alcohol consumption on serum uric acid-an index of oxidant stress status?
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کلمات کلیدی
GGTALTγ-Glutamyl transferase - γ-گلوتامیل ترانسفرازAST - آسپارتات ترانس آمینازAspartate aminotransferase - آسپارتات ترانس آمیناز یا AST Alanine aminotransferase - آلانین آمینوترانسفرازEthanol - اتانولEstrogen - استروژنUrate - اوراتOxidative stress - تنش اکسیداتیوFree radicals - رادیکال آزادbody mass index (kg/m2) - شاخص توده بدن (کیلوگرم در متر مربع)BMI - شاخص توده بدنیObesity - مرض چاقی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Gender-dependent impacts of body mass index and moderate alcohol consumption on serum uric acid-an index of oxidant stress status? Gender-dependent impacts of body mass index and moderate alcohol consumption on serum uric acid-an index of oxidant stress status?](/preview/png/10738761.png)
چکیده انگلیسی
Uric acid seems to be causally involved in a variety of medical disorders involving oxidative stress. Although alcohol abuse and obesity are known to increase serum uric acid, the interactions between moderate drinking, adiposity, and uric acid metabolism have remained poorly understood. We examined serum uric acid concentrations from 2062 apparently healthy volunteers (970 men, 1092 women) reporting either no alcohol (abstainers) or < 40 g of ethanol consumption per day (moderate drinkers). The study population was further classified according to BMI as follows: < 19 (underweight), 19-25 (normal weight), 25-30 (overweight), and > 30 (obese). Serum uric acid concentrations in male moderate drinkers were significantly higher, and in females they were lower, than in the corresponding groups of abstainers. In the BMI-based subgroups, the highest concentrations were found in those who were overweight or obese. Significant two-factor interactions occurred between gender and drinking status (p < 0.001) and between gender and BMI (p < 0.02). Serum uric acid also correlated with indices of hepatocellular health (GGT, ALT, AST). The data indicate distinct gender-dependent impacts of alcohol consumption and BMI on serum uric acid. These findings should be applicable to the assessment of oxidative stress status and associated morbidity in alcohol consumers and individuals with excess body weight.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Free Radical Biology and Medicine - Volume 46, Issue 8, 15 April 2009, Pages 1233-1238
Journal: Free Radical Biology and Medicine - Volume 46, Issue 8, 15 April 2009, Pages 1233-1238
نویسندگان
Päivikki I. Alatalo, Heidi M. Koivisto, Johanna P. Hietala, Risto S. Bloigu, Onni J. Niemelä,