کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10745109 1048706 2016 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The contribution of white matter lesions (WML) to Parkinson's disease cognitive impairment symptoms: A critical review of the literature
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
پیش نمایش صفحه اول مقاله
The contribution of white matter lesions (WML) to Parkinson's disease cognitive impairment symptoms: A critical review of the literature
چکیده انگلیسی
Eight studies described the negative impact of WML on cognition in PD. Patients with mild cognitive impairment (MCI) and dementia had significantly more WML than the group without MCI and dementia. There was significant relationship between increasing total WML volume and worse performance on executive function, memory and language. Patients with vascular parkinsonism and dopaminergic denervation had more severe frontal lobe dysfunctions than patients with PD. In contrast in three studies there was no negative correlation between WML and cognition. Although the progression of neurodegenerative process in advanced stage of PD has been recognized as being mainly responsible for cognitive impairment in PD, WML may also be a contributing factor. It is possible that by reducing the vascular risk factors that cause WML cognitive impairment could be prevented or slowed down.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Parkinsonism & Related Disorders - Volume 22, Supplement 1, January 2016, Pages S166-S170
نویسندگان
, ,