Targeting gemcitabine containing liposomes to CD44 expressing pancreatic adenocarcinoma cells causes an increase in the antitumoral activity

► CD44-mediated uptake of hyaluronated liposomes into cells ► Lipid-raft mediated uptake of hyaluronated liposomes into CD44 expressing cells ► In vitro and in vivo inhibition of cell proliferation by hyaluronated liposomes ► Differential effects of 4.8 kDa MW or 12 kDa MW hyaluronic acid charged liposomes.