Effect of inserting charged peptide at NH2-terminal on N-type inactivation of Kv1.4 channel

► Effect of inserting negatively-charged c-myc tag at NH2-terminal of Kv1.4. ► Effect of inserting negatively-charged D-peptide at the same sites. ► D-peptide decelerated the inactivation to a greater extent than myc-peptide. ► Effect of inserting positively-charged K-peptide at NH2-terminal of Kv1.4. ► The voltage-dependence of inactivation or activation is not changed.