Regulation of voltage-dependent calcium channels by RGK proteins

► RGK proteins inhibit voltage-dependent CaV1 and CaV2 channels. ► RGKs use multiple mechanisms and determinants to inhibit CaV1/CaV2 channels. ► The mechanisms of channel inhibition are customized for different RGK/CaV channel types. ► New functionalities can be engineered into RGKs for practical applications.