Calcium channels and migraine

► Mutations in the CaV2.1 channel gene cause a rare form of migraine with aura (FHM1). ► FHM1 mutations produce gain-of-function of neuronal CaV2.1 channels. ► FHM1 mutations enhance cortical excitatory transmission but do not affect inhibitory transmission. ► FHM1 mutations facilitate cortical spreading depression. ► FHM1 mutations enhance CGRP release at the trigeminal ganglion but not at the dura.