Difference in lipid packing sensitivity of exchangeable apolipoproteins apoA-I and apoA-II: An important determinant for their distinctive role in lipid metabolism

► ApoA-I is more sensitive to lipid packing than ApoA-II. ► The analysis of apoA‐I and apoA‐II clusters reveals a similar mode of self-assembling. ► Spatial distribution analyses of apolipoprotein oligomers in phospholipid monolayers. ► Apolipoprotein size affects the formation of HDL particles.