Structure, activity and interactions of the cysteine deleted analog of tachyplesin-1 with lipopolysaccharide micelle: Mechanistic insights into outer-membrane permeabilization and endotoxin neutralization

► β-hairpin like structure of cysteine deleted analog of tachyplesin-1 (CDT) in lipopolysaccharide (LPS). ► Structure shows cation-π interactions between W4 and R11 at the non-polar surface. ► Structure and interactions of CDT in LPS may provide insights into antimicrobial activity and endotoxin neutralization.