Investigation into the role of phosphatidylserine in modifying the susceptibility of human lymphocytes to secretory phospholipase A2 using cells deficient in the expression of scramblase

► Phosphatidylserine exposure is not an absolute requirement for membrane hydrolysis by secretory phospholipase A2. ► Dying lymphoma cells are more susceptible to hydrolysis by secretory phospholipase A2 than their normal human counterparts. ► Hydrolysis of cell membranes correlates best with physical membrane changes that occur during ionomycin-induced cell death.