Adhesion and hemifusion of cytoplasmic myelin lipid membranes are highly dependent on the lipid composition

► We studied the effect of lipid composition on adhesion and fusion of model myelin lipid membranes. ► The interaction forces between membranes can be well described by a generic model that include the hydrophobic interaction. ► Presence of calcium strongly affects both adhesion and hemifusion of the membranes studied.