Na-glutamine co-transporters B0AT1 in villus and SN2 in crypts are differentially altered in chronically inflamed rabbit intestine

► During chronic intestinal inflammation NGcT was uniquely regulated. ► NGcT was inhibited in villus cells. ► NGcT inhibition was secondary to reduced B0AT1 co-transporters in villus cell BBM. ► NGcT was stimulated in crypt cells. ► NGcT stimulation was via increased affinity of SN2 for glutamine in crypt cell BBM.