Changes in membrane lipid composition cause alterations in epithelial cell-cell adhesion structures in renal papillary collecting duct cells

► Cyclodextrin, neomycin and LiCl provoke membrane lipid redistribution. ► Cyclodextrin treatment promotes E-cadherin internalization. ► Neomycin promotes a non-favorable lipid domain for the adherens junction proteins. ► LiCl changes the relative proportion of membrane neutral and acidic phospholipids. ► Cyclodextrin, neomycin and LiCl provoke dissipation of adherens junctions.