Chaperoning α7 neuronal nicotinic acetylcholine receptors

► The α7 nicotinic acetylcholine receptor (AChR) is one of the most abundant AChR subtypes in the hippocampus. ► This receptor is a potential therapeutic target for important psychiatric diseases. ► RIC-3, a protein originally found in C. elegans, modulates the expression of α7 receptors. ► Modulation of receptor expression by RIC-3 is critically reviewed.