The effect of long-chain bases on polysialic acid-mediated membrane interactions

► polySia chains can mediate cis interactions between ODA and DOPC in ODA/DOPC monolayers. ► polySia chains can disrupt ODA aggregates in ODA/DOPC monolayers. ► polySia chains can mediate trans interactions between apposing ODA/DOPC bilayers. ► polySia chain may function as a multi-bridge attracting the components of ODA/DOPC membranes.