Effects of synaptotagmin 2 on membrane fusion between liposomes that contain SNAREs involved in exocytosis in mast cells

► Mast cell is a key player in allergic responses. ► Mast cell secretes inflammatory mediators by SNARE-dependent exocytosis. ► We investigated the role of synaptotagmin 2 in exocytosis, using liposomes. ► High concentration of synaptotagmin 2 enhanced the SNARE-mediated liposome fusion. ► Low concentration of synaptotagmin 2 inhibited the liposome fusion.