Oxidative stress increases angiotensin receptor type I responsiveness by increasing receptor degree of aggregation using image correlation spectroscopy

►We use ICS to characterize cell surface AT1R distribution pattern in living cells. ►Oxidative stress induces aggregation and hyper-function of AT1R. ►AT1R distribution pattern markedly affects its signaling i.e. increased [Ca2+]i. ►This is possibly caused by oxidant-induced receptor dimerization.