Endocannabinoids and diacylglycerol kinase activity

►Specificity of diacylglycerol kinase does not extend to monoglycerides. ►Monoglycerides inhibit diacylglycerol kinase. ►Inhibition by monoglycerides is lower for the more specific isoform epsilon. ►These results have implications for the known role of DGKε in neuronal function.