Oligomerization of daptomycin on membranes

► Daptomycin is shown to form oligomers on liposome membranes. ► Oligomerization depends on presence of phosphatidylglycerol; phosphatidylcholine membranes bind daptomycin but do not induce oligomerization. ► Lipid requirements for oligomerization correlate with those for antimicrobial activity.